P2Y7 purinoceptor; leukotriene B4 receptor 1; LTB4-R 1; P2Y purinoceptor 7; P2Y7; chemoattractant receptor-like 1; G-protein coupled receptor 16 (LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7)

Function

• receptor for extracellular ATP > UTP & ADP
• activity is mediated by G proteins which activate phosphatidylinositol-Ca+2 second messenger system
• may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type Ca+2 currents
• receptor for leukotriene B4
• phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Expression

• expressed in heart, skeletal muscle > brain & liver
• high level of expression in lymphoid tissues

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• leukotriene receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1241
• OMIM: https://mirror.omim.org/entry/601531
• UniProt: http://www.uniprot.org/uniprot/Q15722.html