G protein-coupled receptor kinase-6 (GRK6, GPRK6)

Function

• specifically phosphorylates activated forms of G protein-coupled receptors

ATP + [G-protein-coupled receptor]
                <-->
ADP + [G-protein-coupled receptor] phosphate

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain
• contains 1 RGS domain
• uncertain whether palmitoylation is on Cys-561 &/or Cys-562 &/or Cys-565

Compartment

membrane; lipid-anchor

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• G protein-coupled receptor kinase
• phosphoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/600869
• UniProt: http://www.uniprot.org/uniprot/P43250.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2870