P2Y5 purinoceptor; oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; purinergic receptor 5; RB intron encoded G-protein coupled receptor (P2RY5, LPAR6)

Function

• binds to oleoyl-L-alpha-lysophosphatidic acid (LPA)
• intracellular cAMP is involved in the receptor activation
• important for the maintenance of hair growth & texture

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Expression

• expressed ubiquitously, including in skin & hair follicle cells
• detected in both Henle's & Huxley's layers of the inner root sheath of the hair follicle & in suprabasal layers of the epidermis (at protein level)
• expressed at low levels in peripheral blood leukocytes
• markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway
• not detectable in undifferentiated HL60 cells
• only low levels after the induction of differentiation along the granulocytic pathway

Pathology

• defects in P2RY5 are a cause of:
  • autosomal recessive woolly hair
  • localized autosomal recessive hypotrichosis type 3

Genetics

• gene is nested within intron 17 of the retinoblastoma gene

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1016
• OMIM: https://mirror.omim.org/entry/278150
• OMIM: https://mirror.omim.org/entry/609239
• OMIM: https://mirror.omim.org/entry/611452
• UniProt: http://www.uniprot.org/uniprot/P43657.html