C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; LARC receptor; GPR-CY4; GPRCY4; chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; CD196 (CCR6, CKRL3, CMKBR6, GPR29, STRL22)

Function

• receptor for a C-C type chemokine
• binds to MIP-3- alpha/LARC
• transduces a signal by increasing the intracellular Ca+2

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in spleen, lymph nodes, appendix, & fetal liver
• expressed in lymphocytes, T-cells & B-cells but not in natural killer cells, monocytes or granulocytes
• induced by interleukin-2

Notes

uncertain whether Met-1 or Met-6 is the initiator

More general terms

• CC chemokine receptor
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1235
• OMIM: https://mirror.omim.org/entry/601835
• UniProt: http://www.uniprot.org/uniprot/P51684.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1235