sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3; endothelial differentiation G-protein coupled receptor 3 (S1PR3, EDG3)

Function

• receptor for the lysosphingolipid sphingosine 1-phosphate (S1P)
• when expressed in rat HTC4 hepatoma cells, capable of mediating S1P-induced cell proliferation & suppression of apoptosis

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in all tissues
• expressed most abundantly in heart, placenta, kidney, & liver

More general terms

• lysophosphatidic acid receptor (LPA-R)
• sphingosine 1-phosphate receptor; S1P receptor (S1PR)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1903
• OMIM: https://mirror.omim.org/entry/601965
• UniProt: http://www.uniprot.org/uniprot/Q99500.html