neuropeptide Y receptor type 4; NPY4-R; pancreatic polypeptide receptor 1; PP1 (PPYR1, NPY4R)

Function

• receptor for neuropeptide Y & peptide YY
• rank order of affinity for pancreatic polypeptides is: PP, PP (2-36) & [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY & [Leu-31, Pro-34] NPY > NPY > PYY (3-36) & NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• highest levels found in brain, coronary artery & ileum
• low levels in pancreas & kidney. detected in colon & small intestine

More general terms

• neuropeptide Y receptor

Additional terms

• neuropeptide Y; Proneuropeptide Y contains: neuropeptide Y; neuropeptide tyrosine; NPY; C-flanking peptide of NPY; CPON (NPY)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5540
• OMIM: https://mirror.omim.org/entry/601790
• UniProt: http://www.uniprot.org/uniprot/P50391.html