POU domain, class 3, transcription factor 2; brain-specific homeobox/POU domain protein 2; brain-2; Brn-2; nervous system-specific octamer-binding transcription factor N-Oct-3; octamer-binding protein 7; Oct-7; octamer-binding transcription factor 7; OTF-7 (POU3F2, BRN2, OCT7 OTF7, OCT5)

Introduction

OTF5A & OTF5B formed from common precursor.

Function

• transcription factor & DNA-binding protein
• binds preferentially to the recognition sequence which consists of two distinct half-sites, 'GCAT' & 'TAAT', separated by a nonconserved spacer region of 0, 2, or 3 nucleotides
• positively regulates the genes under control of corticotropin-releasing hormone (CRH) & CRH II promoters (putative)
• interacts with PQBP1

Structure

• belongs to the POU transcription factor family, class- 3 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

nucleus

Alternative initiation

named isoforms=3

Expression

• expressed specifically in the neuroectodermal cell lineage

More general terms

• octamer transcription factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5454
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5454
• OMIM: https://mirror.omim.org/entry/600494
• UniProt: http://www.uniprot.org/uniprot/P20265.html