keratin, type 2 cytoskeletal 2 epidermal; cytokeratin-2e; CK 2e; K2e; keratin-2 (KRT2, KRT2A, KRT2E)

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Function

probably contributes to terminal cornification associated with keratinocyte activation, proliferation & keratinization
associates with KRT10 (putative)

expressed in upper spinous & granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft & axilla
not present in foreskin, squamous metaplasias & carcinomas
expression in hypertrophic & keloid scars begins in the deepest suprabasal layer. weakly expressed in normal gingiva & tongue, however expression is induced in benign keratoses of lingual mucosa & in mild-to-moderate oral dysplasia with orthokeratinization
synthesized during maturation of epidermal keratinocytes & localized in the upper intermediate cells offetal skin
earliest expression is at 10 weeks in the developing embryo in the presumptive nail bed of developing digits, shifting to the proximal nail fold by 13.5 weeks
at 12.5 weeks, detected in scattered cells of the intermediate layer of trunk skin
at 19.3 weeks, regional expression patterns were observed in upper intermediate keratinocytes of cheek, trunk, dorsal & ventral knee, elbow & dorsal hand
distal areas around the periumbilical region showed increased number of positive cells & by 15 weeks is expressed in small groups of cells in the fetal hair follicles