betaine-homocysteine S-methyltransferase 2 (BHMT2)
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Function
- involved in regulation of homocysteine metabolism
- converts betaine to dimethylglycine & homocysteine to methionine
- amine & polyamine degradation, betaine degradation, sarcosine from betaine, step 1/2
- amino-acid biosynthesis, L-methionine biosynthesis
- role in oxidation of choline
- may interact with PRNP
- binds 1 Zn+2 per subunit
Structure
- homotetramer
- contains 1 Hcy-binding domain
Expression
- expressed in liver & kidney > brain, heart, skeletal muscle