betaine (trimethylglycine)
Jump to navigation
Jump to search
Comparative biology
- repeated exercise triggers adaptive changes, reducing inflammation & enhancing betaine metabolism
- exercise-driven betaine enrichment, partly mediated by renal biosynthesis, exerts geroprotective effects & rescues age-related health decline in mice.
- betaine binds to & inhibits TANK-binding kinase 1 (TBK1), slowing the kinetics of aging[1]
More general terms
Component of
References
- ↑ 1.0 1.1 Ledford H Can a pill replace exercise? Swigging this molecule gives mice benefits of working out. Nature News. June 25, 2025 https://www.nature.com/articles/d41586-025-01994-0
Geng L, Wu R, Yan H et al Systematic profiling reveals betaine as an exercise mimetic for geroprotection. Cell. 2025 Sep 18;188(19):5403-5425.e33. PMID: https://pubmed.ncbi.nlm.nih.gov/40570836 Cell. 2025 Sep 18;188(19):5426-5428 PMID: https://pubmed.ncbi.nlm.nih.gov/40803320 https://www.cell.com/cell/abstract/S0092-8674(25)00635-X