betaine-homocysteine S-methyltransferase

Introduction

Two forms.

Function

• role in regulation of homocysteine metabolism
• converts betaine to dimethylglycine & & homocysteine to methionine
• required for irreversible oxidation of choline
• amine & polyamine degradation; betaine degradation sarcosine from betaine: step 1/2
• amino-acid biosynthesis;
• L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1

trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine

More general terms

• S-methyltransferase
• oligomerizing protein

More specific terms

• betaine-homocysteine S-methyltransferase 1 (BHMT)
• betaine-homocysteine S-methyltransferase 2 (BHMT2)

Additional terms

• betaine
• homocysteine