sialidase-3; ganglioside sialidase; membrane sialidase; N-acetyl-alpha-neuraminidase 3 (NEU3)

Function

• role in modulating the ganglioside content of the lipid bilayer (membrane-bound sialyl glycoconjugates)
• hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid & synthetic substrates

Kinetic parameters:

• pH dependence: optimum pH is 3.8

Structure

• belongs to the glycosyl hydrolase 33 family
• contains 3 BNR repeats

Compartment

• membrane; peripheral membrane protein

Expression

• expressed in skeletal muscle, testis, adrenal gland & thymus > pancreas, liver, heart & thymus > kidney, placenta, brain & lung

More general terms

• sialidase
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604617
• UniProt: http://www.uniprot.org/uniprot/Q9UQ49.html