neutral alpha-glucosidase AB; glucosidase 2 alpha subunit (GANAB, G2AN, KIAA0088)

Function

• cleaves sequentially 2 innermost alpha-1,3-linked glucose residues from the Glc(2)man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins
• binds glycosylated PTPRC (putative)
• glycan metabolism; N-glycan metabolism
• hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans

Structure

• heterodimer of a catalytic alpha subunit (GANAB) & a beta subunit (PRKCSH)
• belongs to the glycosyl hydrolase 31 family

Compartment

• endoplasmic reticulum (putative)
• Golgi
• melanosome

Alternative splicing

named isoforms=3

Expression

detected in placenta

More general terms

• glucosidase

Component of

• glucosidase 2

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23193
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23193
• OMIM: https://mirror.omim.org/entry/104160
• UniProt: http://www.uniprot.org/uniprot/Q14697.html