claudin-8 (CLDN8)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space (putative)
• directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3 (putative)

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein
• localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, & in the corpus at the interface between basal & principal cells

Expression

• expressed in the epididymis, mainly in the caput segment

More general terms

• claudin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9073
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9073
• OMIM: https://mirror.omim.org/entry/611231
• UniProt: http://www.uniprot.org/uniprot/P56748.html