tripartite motif-containing protein 35; hemopoietic lineage switch protein 5 (TRIM35, HLS5, KIAA1098)

Function

• may play a role as a tumor suppressor
• implicated in the cell death mechanism (putative)

Structure

• the RING finger domain & the coiled-coil region are required for the apoptosis-inducing activity (putative)
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm (putative)
• nucleus
• found predominantly in cytoplasm with a granular distribution
• found in punctuate nuclear bodies (putative)

Alternative splicing

named isoforms=2

More general terms

• tripartite motif-containing protein (trim protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23087
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23087
• UniProt: http://www.uniprot.org/uniprot/Q9UPQ4.html