DNA replication licensing factor MCM8; minichromosome maintenance 8 (MCM8, C20orf154)

Function

• may play a role in the control of cell proliferation
• appears to be involved in activation of the pre-replication complex during G(1) phase by recruiting CDC6 to the origin recognition complex
• binds chromatin throughout the cell cycle
• interacts with CDC6 & ORC2L

Structure

• belongs to the MCM family
• contains 1 MCM domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• highest levels in placenta, lung & pancreas
• low levels in skeletal muscle & kidney
• expressed in various tumors with highest levels in colon cancer & lung cancer

More general terms

• minichromosome maintenance (Mcm) protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84515
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84515
• OMIM: https://mirror.omim.org/entry/608187
• UniProt: http://www.uniprot.org/uniprot/Q9UJA3.html