blood group beta-1,6-N-acetylglucosaminyltransferase; I-branching enzyme (IGNT, GCNT2, GCNT5, NACGT1)
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Function
- branching enzyme
- converts linear into branched poly-N-acetyllactosaminoglycans
- introduces the blood group I antigen during embryonic development
- closely associated with development & maturation of erythroid cells
- protein modification; protein glycosylation
UDP-N-acetyl-D-glucosamine +
beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
<-->
UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-
1,4-N-acetyl-D-glucosaminyl-R
Structure
belongs to the glycosyltransferase 14 family
Compartment
Golgi membrane
Expression
- in the adult, expressed in prostate > small intestine & colon barely detected in heart, brain, kidkey & pancreas no expression in placenta, lung, liver, skeletal muscle, spleen, thymus, testis, ovary & peripheral blood leukocytes
- in fetus, expressed in brain > lung & kidney barely detected in liver
- expression increases dramatically during development & oncogenesis
More general terms
More specific terms
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 (GCNT7, C20orf105)
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A; N-acetylglucosaminyltransferase; I-branching enzyme; IGNT (GCNT2, GCNT5, NACGT1)
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C; N-acetylglucosaminyltransferase; I-branching enzyme; IGNT (GCNT2, GCNT5, II NACGT1)
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q06430 (withdrawn from UniProt 10/16).html
- ↑ GGDB; Note: glycogene database http://ggdb.muse.aist.go.jp/GGDB/index.jsp