N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A; N-acetylglucosaminyltransferase; I-branching enzyme; IGNT (GCNT2, GCNT5, NACGT1)

Function

• branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans
• introduces the blood group I antigen during embryonic development
• closely associated with development & maturation of erythroid cells
• expression of the blood group I antigen in erythrocytes is determined by isoform C
• protein modification; protein glycosylation

Structure

belongs to the glycosyltransferase 14 family

Compartment

• Golgi membrane; single-pass type 2 membrane protein

Alternative splicing

named isoforms=3; A, B & C

Expression

• expressed in reticulocytes

More general terms

• beta-1,6-acetylglucosaminyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2651
• OMIM: https://mirror.omim.org/entry/110800
• OMIM: https://mirror.omim.org/entry/600429
• UniProt: http://www.uniprot.org/uniprot/Q8N0V5.html