N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C; N-acetylglucosaminyltransferase; I-branching enzyme; IGNT (GCNT2, GCNT5, II NACGT1)
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Function
- branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans
- introduces the blood group I antigen during embryonic development
- closely associated with the development & maturation of erythroid cells
- expression of the blood group I antigen in erythrocytes is determined by isoform C
- protein modification; protein glycosylation
Structure
belongs to the glycosyltransferase 14 family
Compartment
- Golgi membrane; single-pass type 2 membrane protein (putative)
Alternative splicing
named isoforms=3; A, B & C
Expression
- expressed in reticulocytes
- expressed in lens epithelium
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q8NFS9 (withdrawn from UniProt 10/16).html
- ↑ GGDB; Note: glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/homolog?cat=symbol&symbol=GCNT2
- ↑ Functional glycomics gateway - GTase; Note: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_548