fucosyltransferase-7; alpha (1,3) fucosyltransferase (FUT7)

Function

• may catalyze alpha-1,3 glycosidic linkages involved in expression of sialyl Lewis X antigens
• protein modification; protein glycosylation

GDP-L-fucose + alpha-2,3-neu-N-acetyl-1,4-beta-D-galactosyl- N-acetyl-D-glucosaminyl-R
      <-->
GDP + alpha-2,3-neu-N-acetyl-1,4-beta-D-galactosyl- (alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Structure

belongs to the glycosyltransferase 10 family

Compartment

• Golgi, Golgi membrane
• membrane-bound form in trans cisternae of Golgi

Expression

myeloid lineage cells

More general terms

• fucosyltransferase

Additional terms

• alpha-(1,3)-fucosyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q11130.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2529
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2529
• OMIM: https://mirror.omim.org/entry/602030