fucosyltransferase-6; alpha (1,3) fucosyltransferase (FUT6, FCT3A)

Function

• enzyme involved in the biosynthesis of E-selectin ligand, sialyl-Lewis X
• catalyzes transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
• protein modification; protein glycosylation

GDP-beta-L-fucose +  beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R
          <-->
GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))- N-acetyl-beta-D-glucosaminyl-R

Structure

belongs to the glycosyltransferase 10 family

Compartment

• Golgi, Golgi membrane
• membrane-bound form in trans cisternae of Golgi

Alternative splicing

named isoforms=2

Expression

• expressed in kidney, liver, colon, small intestine, bladder, uterus & salivary gland

More general terms

• fucosyltransferase

Additional terms

• alpha-(1,3)-fucosyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2528
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2528
• OMIM: https://mirror.omim.org/entry/136836
• UniProt: http://www.uniprot.org/uniprot/P51993.html