high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)

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Function

guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

Cofactor:

Inhibition:

  • inhibited by zaprinast

Structure

Compartment

Alternative splicing

named isoforms=16

Expression

Comparative biology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/O76083.html
  2. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5152
  3. 3.0 3.1 Lee DI, Zhu G, Sasaki T et al. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature 2015 Mar 26; 519:472 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25799991
    Kuhn M. A big-hearted molecule. Nature 2015 Mar 26; 519:416 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25799985

Database