cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; cGMP phosphodiesterase 6C (PDE6Cc, PDEA2)

Function

• guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2 (putative)
• component of oligomer of two alpha' subunits (PDE6C) that are associated with 3 smaller proteins of 11, 13, & 15 kDa

Structure

• belongs to the cyclic nucleotide phosphodiesterase family
• contains 2 GAF domains

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

Pathology

• defects in PDE6C are the cause of cone dystrophy type 4

More general terms

• phosphodiesterase 6
• prenyl protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5146
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5146
• OMIM: https://mirror.omim.org/entry/600827
• OMIM: https://mirror.omim.org/entry/613093
• UniProt: http://www.uniprot.org/uniprot/P51160.html