myosin-15; unconventional myosin-15 (MYO15A, MYO15)

Function

• myosins are actin-based motor molecules with ATPase activity
• unconventional myosins serve in intracellular movements
• their highly divergent tails are presumed to bind to membrane compartments, which would be moved relative to actin filaments
• required for the arrangement of stereocilia in mature hair bundles
• interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips
• interacts with FASLG

Structure

• contains 1 FERM domain
• contains 3 IQ domains
• contains 1 myosin head-like domain
• contains 2 MyTH4 domains
• contains 1 SH3 domain

Compartment

• cell projection, stereocilium
• cytoplasm, cytoskeleton (putative)
• localizes to stereocilium tips in cochlear & vestibular hair cells (putative)

Expression

• highly expressed in pituitary
• also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta & skeletal muscle
• not expressed in brain
• highly expressed in anterior pituitary cells

Pathology

• defects in MYO15A are the cause of autosomal recessive neurosensory deafness 3

More general terms

• unconventional myosin

Additional terms

• autosomal recessive neurosensory deafness 3 (DFNB3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51168
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51168
• OMIM: https://mirror.omim.org/entry/600316
• OMIM: https://mirror.omim.org/entry/602666
• UniProt: http://www.uniprot.org/uniprot/Q9UKN7.html