exonuclease GOR; antigen GOR homolog; RNA exonuclease 1 homolog-like 1 (REXO1L1, GOR)

Function

• exoribonuclease by default; substrate unknown

Structure

• belongs to the REXO1/REXO3 family
• contains 1 exonuclease domain

Compartment

cytoplasm, nucleus (probable) Evolutionary biology:

• human GOR does not contain the GOR47-1 epitope present in chimpanzee GOR

Pathology

• individuals with hepatitis C may have antibodies against the GOR47-1 epitope, despite its absence in humans

Notes

• could be the product of a pseudogene
• uncertain whether Met-1 or Met-47 is the initiator

More general terms

• exoribonuclease
• evolutionary divergent human protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=254958
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:254958
• UniProt: http://www.uniprot.org/uniprot/Q8IX06.html