chromosomal translocation t11q21:19.p13 (mucoepidermoid carcinomas)
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Introduction
A chromosomal translocation t(11;19)(q21;p13) involving CRTC1 with MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors & clear cell hidradenomas. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.