dapper homolog 2 (DACT2, C6orf116, PP13671)

Function

• negatively regulates the nodal signaling pathway, possibly by promoting the lysosomal degradation of nodal receptors

Structure

• C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (dishevelled) family proteins
• belongs to the dapper family

Alternative splicing

named isoforms=4

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1680
• UniProt: http://www.uniprot.org/uniprot/Q5SW24.html