A-kinase anchor protein SPHKAP (SPHK1-interactor & AKAP domain-containing protein, sphingosine kinase type 1-interacting protein, SPHKAP, KIAA1678, SKIP)

Function

• anchoring protein that mediates subcellular compartmentation of cAMP-dependent protein kinase (PKA2)
• may act as a converging factor linking cAMP & sphingosine signaling pathways
• plays a regulatory role in the modulation of SPHK1
• interacts with RII subunit of PKA (putative)
• interacts with SPHK1

Structure

• RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (putative)
• belongs to the AKAP110 family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• highly expressed in heart
• also expressed in spleen, ovary & brain

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q2M3C7.html