myeloproliferative disease-associated 6 kD antigen (MPD6, LUZP6)
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Expression
- widely expressed
- highest levels found in brain, placenta, spleen, testis, & ovary
- up-regulated in some tumor cells
- induced by IFNA1
Pathology
- elicits IgG antibody response in a subset of polycythemia vera, chronic myelogenous leukemia & prostate cancer patients receiving IFNA1 or other therapy, suggesting that it is broadly immunogenic
Genetics
- produced by a bicistronic gene which also produces the MTPN protein from a non-overlapping reading frame
- MPD6 belongs to a group of cryptic antigens without conventional genomic structure
- it is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN