myotrophin; protein V-1 (MTPN)

Function

• potential role in cerebellar morphogenesis
  • may function in differentiation of cerebellar neurons, particularly granule cells
• seems to be associated with cardiac hypertrophy

Structure

• belongs to the myotrophin family
• contains 3 ANK repeats

Compartment

cytoplasm (putative)

Expression

ubiquitous

Genetics

• protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame
• MPD6 belongs to a group of cryptic antigens without conventional genomic structure
• it is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=136319
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:136319
• OMIM: https://mirror.omim.org/entry/606484
• UniProt: http://www.uniprot.org/uniprot/P58546.html