lamin-C
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Function
- lamins are components of the nuclear lamina (see lamin)
- lamin A & lamin C filaments cross-link into an orthogonal lattice (nuclear lamina), which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor
- increased phosphorylation of the lamins occurs before nuclear envelope disintegration & probably plays a role in regulating lamin associations
Structure
- homodimer of lamin A & lamin C.
- belongs to the intermediate filament family
More general terms
References
- ↑ Holtz D et al The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope. Cell 59:969 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2557160
- ↑ UniProt http://www.uniprot.org/uniprot/P02545.html