complications of lupus erythematosus
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Complications
Life threatening complications:
- glomerulonephritis
- central nervous system disease
- seizures
- psychosis associated with
- increased generalized SLE disease activity
- high antiphospholipid antibody titers
- organic brain syndrome
- hematologic disease
- infectious complications of treatment
- pulmonary
- myocarditis
- vasculitis of the gastrointestinal tract
Other complications
- avascular osteonecrosis
- accelerated coronary artery disease[4]
- hypertension
- osteoporosis[2]
- hyperlipidemia
- higher prevalence of cervical intraepithelial neoplasia[3]
- leukocytoclastic vasculitis (image)[5]
Management
- Life-threatening complications
- prednisone 1 mg/kg/day for non-infectious complications
- the combination of cyclophosphamide plus prednisone is superior to prednisone alone in preventing renal failure
- psychosis treated with
- glucocorticoids alone or in combination with immunosuppressive agent[2]
- antiplatelet &/or anticoagulation therapy if high high antiphospholipid antibody titers[2]
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, 16. American College of Physicians, Philadelphia 1998, 2012
- ↑ Jump up to: 2.0 2.1 2.2 2.3 Bertsias GK, Boumpas DT. Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations. Nat Rev Rheumatol. 2010 Jun;6(6):358-67 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20458332
- ↑ Jump up to: 3.0 3.1 Klumb EM, Araujo ML Jr, Jesus GR et al Is higher prevalence of cervical intraepithelial neoplasia in women with lupus due to immunosuppression? J Clin Rheumatol. 2010 Jun;16(4):153-7 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20407390
- ↑ Jump up to: 4.0 4.1 Pons-Estel GJ, Gonzalez LA, Zhang J Predictors of cardiovascular damage in patients with systemic lupus erythematosus: data from LUMINA (LXVIII), a multiethnic US cohort. Rheumatology (Oxford). 2009 Jul;48(7):817-22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19454606
- ↑ Jump up to: 5.0 5.1 Yang L, Zeng YP Images in Dermatology. Cutaneous Vasculitis in Systemic Lupus Erythematosus. JAMA Dermatol. 2021;157(8):991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34160552 https://jamanetwork.com/journals/jamadermatology/fullarticle/2781365
- ↑ What People with Lupus Need to Know About Osteoporosis http://www.osteo.org/newfile.asp?doc=r801i&doctitle=What+People+with+Lupus+Need+to+Know+About+Osteoporosis&doctype=HTML+Fact+Sheet