NSAID enterocolopathy
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Epidemiology
- most patients are > 50 years of age
Pathology
- may cause ulcerations, strictures & perforations of the small bowel & colon when enteric-coated & slow-release preparations are used
- colonic lesions are most frequently in the cecum & ascending colon
Clinical manifestations
- diarrhea[2]
- chronic blood loss & iron-deficiency anemia[2]
- worsening of inflammatory bowel disease[2]
Laboratory
- colonoscopy is recommended for evaluation of colonic bleeding in patients taking NSAIDs
Radiology
- strictures may be difficult to detect using barium contrast studies
Management
- discontinuation of NSAIDs generally results in healing of lesions in 6-8 weeks
- re-evaluation in 4-6 weeks
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ 2.0 2.1 2.2 2.3 Davies NM. Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine. Dis Colon Rectum. 1995 Dec;38(12):1311-21. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7497845 Review