osteitis fibrosa cystica; von Recklinghausen's disease of bone
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Etiology
- sustained hyperparathyroidism
- most commonly seen in patients with chronic renal failure
- rarely seen with severe primary hyperparathyroidism[1]
Epidemiology
- now uncommon
- in the past 25% of patients with hyperparathyroidism
Pathology
- increased osteoclastic resorption of calcified bone with replacement by soft tissue
- increased multinucleated osteoclasts
- reduction in the number or trabecula
- bone cysts
Radiology
- punched-out lesions in the skull
- subperiosteal absorption of bone in the digits
* images[4]
Differential diagnosis
More general terms
References
- ↑ Jump up to: 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 18. American College of Physicians, Philadelphia 1998, 2018
- ↑ Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1253
- ↑ Jump up to: 4.0 4.1 Ramon A, Berthod PE Images in Clinical Medicine. Osteitis Fibrosa Cystica. N Engl J Med 2020; 382:e15. March 12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32160666 https://www.nejm.org/doi/full/10.1056/NEJMicm1907828?query=TOC