centriolin; 110 kD centrosomal protein; centrosomal protein 1 (CNTRL, CEP110, CEP1, KIAA0419)

Function

• role in cell cycle progression & cytokinesis
• during the late steps of cytokinesis, anchors exocyst & SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission
• interacts with HOOK2 (putative)
• interacts with EXOC6 & SNAPAP
• associates with the exocyst complex

Structure

contains 21 LRR repeats (leucine-rich repeats)

Compartment

• centrosome
• during cytokinesis, localizes to a ring-like structure at the central midbody

Alternative splicing

named isoforms=5

Expression

highly expressed in testis & trachea

Pathology

• chromosomal translocation t(8;9)(p12;q33) involving CEP110 with FGFR1 may be a cause of stem cell myeloproliferative disorder
• the fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity & may be responsible for the transforming activity

More general terms

• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1106
• OMIM: https://mirror.omim.org/entry/605496
• UniProt: http://www.uniprot.org/uniprot/Q7Z7A1.html
• UniProt: http://www.uniprot.org/uniprot/O43303.html