hook homolog 2 (h-hook2, hHK2, HOOK2)

Function

• cytoskeletal linker protein
• role in tethering membrane bound organelles to cytoskeleton
• interacts with microtubules

Structure

• homodimer
• large coiled coil domain probably mediates homodimerization
• belongs to the hook family

Compartment

• cytoplasm
• associates with discrete punctate structure that correspond to neither early or late endosomes, lysosomes, multivesicular bodies (MVBs), Golgi complex, endoplasmic reticulum, nor mitochondria

Alternative splicing

named isoforms=2

More general terms

• cytoskeletal protein

Database

• OMIM: https://mirror.omim.org/entry/607824
• UniProt: http://www.uniprot.org/uniprot/Q96ED9.html