chromosomal translocation t(8;9)(p12;q33)
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Introduction
- chromosomal translocation t(8;9)(p12;q33) involving CEP110 with FGFR1 may be a cause of stem cell myeloproliferative disorder
- the fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity & may be responsible for the transforming activity