ATP-dependent RNA helicase DDX23; 100 kD U5 snRNP-specific protein; DEAD box protein 23; PRP28 homolog; U5-100kD (DDX23)

Function

• role in pre-mRNA splicing (putative)
• component of U5 & U5.4/6 snRNP complexes
• in vitro phosphorylated by CLK1 & U1 snRNP-associated protein kinase
• identified in the spliceosome C complex
• interacts with ERBB4

Structure

• belongs to the DEAD box helicase family, DDX23/PRP28 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

nucleus

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• phosphoprotein

Component of

• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9416
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9416
• OMIM: https://mirror.omim.org/entry/612172
• UniProt: http://www.uniprot.org/uniprot/Q9BUQ8.html