aphakia

Introduction

Congenital absence of the crystalline lens of the eye

Epidemiology

rare

Pathology

• early developmental arrest, around the 4th-5th week of gestation that prevents formation of any lens structure & leads to severe secondary ocular defects, including aplasia of anterior segment of eye (primary congenital aphakia)
• in secondary aphakia, lens induction has occurred, & lens vesicle has developed to some degree but finally has progressively resorbed perinatally resulting in less-severe ocular defects

Genetics

• associated with defects in FOXE3 gene

More general terms

• ocular lens disorder
• developmental disorder

Database

• OMIM: https://mirror.omim.org/entry/610256