hypertrophic pyloric stenosis (IHPS, HPS)
Jump to navigation
Jump to search
Etiology
- erythromycin (8-fold risk in 1st 1 weeks of life)
- bottle-fed infants at higher risk for pyloric stenosis than breast-fed infants[5]
Epidemiology
- infants
- 1-5 per 1000 live births in whites
- male:female ratio of 4:1
- most frequent disorder requiring surgery in the 1st year of life
Pathology
- hypertrophy & hyperplasia of the circular muscle layer of the pylorus
- defective pyloric relaxation & increased pyloric smooth muscle mass havebeen suggested to be responsible for gastric-outlet obstruction
- bottle-fed infants ingest a larger volume of milk & retain it for a longer period of time in the stomach; burden of overfeeding may challenge the pylorus muscle & lead to hypertrophy[5]
Clinical manifestations
- persistent vomiting 2-12 weeks after birth
Management
- surgical correction
More general terms
References
- ↑ Journal Watch 22(16):128, 2002 Cooper WO, Griffin MR, Arbogast P, Hickson GB, Gautam S, Ray WA. Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. Arch Pediatr Adolesc Med. 2002 Jul;156(7):647-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12090829
- ↑ OMIM https://mirror.omim.org/entry/179010
- ↑ Wikipedia; Note: Nitric oxide synthase entry http://en.wikipedia.org/wiki/Nitric_oxide_synthase
- ↑ UniProt http://www.uniprot.org/uniprot/P29475.html
- ↑ 5.0 5.1 5.2 Krogh C et al Bottle-feeding and risk of pyloric stenosis. Pediatrics, Sept 17, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22945411 <Internet> http://pediatrics.aappublications.org/content/early/2012/08/28/peds.2011-2785.full.pdf+html