medication compliance (taking medicine)

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[1][2][3][4][5][6][7][8][9][10][11][12][13]

Introduction

Taking medication as prescribed. ,

Depression may compromise medication compliance.[1]

Pharmacy-dispensed custom blister packs improves compliance[2]

Adherence to antihypertensive drug treatment is poor[3]

  • 50% of patients self discontinue within 1 year
  • 10% of doses skipped on any given day
  • 95% of patients miss at least 1 dose/year
  • 50% miss at least 1 dose monthly
  • 50% take at least 1 drug holiday of at least 3 days yearly

Patients are less likely to be compliant with their medications after CABG than after PCI[6]

  • direct observation benefits are not sustained past the period of direct observation[4]
  • outcome benefits of medication adherence may exceed benefits of the medications themselves (based on clinical trial data) confounding estimates of the true benefit of adherence[5]

systems approach suggested[9]

most commercially-available electronic adherence monitoring devices do capture whether patients adhere to drug regimens[10]

patients who read visit notes have a better understanding of prescribed medications

More general terms

More specific terms

Additional terms

References

  1. ↑ 1.0 1.1 Gehi A et al, Depression and medication adherence in outpatients with coronary heart disease: Findings from the Heart and Soul Study. Arch Intern Med 2005; 165:2508 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16314548
    Katon W et al, Impact of antidepressant drug adherence on comorbid medication use and resource utilization. Arch Intern Med 2005; 165:2497 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16314547
  2. ↑ 2.0 2.1 Lee JK et al, Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: A randomized controlled trial. JAMA 2006, 296 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17101639
    Simpson RJ JR Challenges for improving medication adherenece. JAMA 2006, 296 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17101641
  3. ↑ 3.0 3.1 Vrijens B et al, Adherence to prescribed antihypertensive drug treatments: Longitudinal study of electronically compiled dosing histories. BMJ 2008, 336:1114 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18480115
  4. ↑ 4.0 4.1 Berg KM et al. Lack of sustained improvement in adherence or viral load following a directly observed antiretroviral therapy intervention. Clin Infect Dis 2011 Nov 1; 53:936 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21890753
  5. ↑ 5.0 5.1 LaFleur J, Nelson RE, Sauer BC, Nebeker JR. Overestimation of the effects of adherence on outcomes: a case study in healthy user bias and hypertension. Heart. 2011 Nov;97(22):1862-9. Epub 2011 May 17. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21586421
  6. ↑ 6.0 6.1 Hlatky MA et al. Use of medications for secondary prevention after coronary bypass surgery compared with percutaneous coronary intervention. J Am Coll Cardiol 2013 Jan 22; 61:295. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23246391
  7. ↑ Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011 Feb;9(1):11-23. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21459305
  8. ↑ 8.0 8.1 Thakkar J et al. Mobile telephone text messaging for medication adherence in chronic disease: A meta-analysis. JAMA Intern Med 2016 Feb 1; PMID: https://www.ncbi.nlm.nih.gov/pubmed/26831740
    Nieuwlaat R et al. Mobile text messaging and adherence of patients to medication prescriptions: A txt a dA keeps da doctR awA? JAMA Intern Med 2016 Feb 1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26831149
  9. ↑ 9.0 9.1 Lauffenburger JC, Choudhry NK. A Call for a Systems-Thinking Approach to Medication Adherence. Stop Blaming the Patient. JAMA Intern Med. Published online May 21, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29799994 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2681650
  10. ↑ 10.0 10.1 Lou N. Rx Adherence Monitors Do Work... Mostly. Not all could record time of opening, however, in controlled lab experiments. MedPage Today. May 21, 2018 https://www.medpagetoday.com/primarycare/generalprimarycare/73004
    McGrady ME, et al An independent evaluation of the accuracy and usability of electronic adherence monitoring devices. Ann Intern Med 2018; PMID: https://www.ncbi.nlm.nih.gov/pubmed/29800004
  11. ↑ 11.0 11.1 Choudhry NK, Isaac T, Lauffenburger JC et al. Effect of a remotely delivered tailored multicomponent approach to enhance medication taking for patients with hyperlipidemia, hypertension, and diabetes: The STIC2IT cluster randomized clinical trial. JAMA Intern Med 2018 Aug 6; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30083727
  12. ↑ DesRoches CM, Bell SK, Dong Z et al. Patients managing medications and reading their visit notes: A survey of OpenNotes participants. Ann Intern Med 2019 May 28; PMID: https://www.ncbi.nlm.nih.gov/pubmed/31132794 https://annals.org/aim/article-abstract/2734788/patients-managing-medications-reading-visit-notes-survey-opennotes-participants?doi=10.7326%2fM18-3197
    Blumenthal D, Abrams MK. Ready or not, we live in an age of health information transparency. Ann Intern Med 2019 May 28; PMID: https://www.ncbi.nlm.nih.gov/pubmed/31132792 https://annals.org/aim/article-abstract/2734888/ready-we-live-age-health-information-transparency?doi=10.7326%2fM19-1366
  13. ↑ Taking Medicine: NIH Senior Health http://nihseniorhealth.gov/takingmedicines/toc.html
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