Global Registry of Acute Coronary Events (GRACE) study

Introduction

,Global Registry of Acute Coronary Events (GRACE)

Study characteristics:

• Cohort study
• 94 hospitals in 14 countries
• 19,537 patients presenting with acute coronary syndrome
• April 1999 to September 2002

Groups:

• Statin use before presentation (1a)
• Statin use discontinued upon hospital admission (1b)
• Statin started after presentation (2)
• No statin use (3)

End points:

• death, in-hospital myocardial infarction, & stroke

Results:

• patients in group 1 were less likely to have
  • ST-segment elevation (odds ratio 0.79)
  • myocardial infarction (OR 0.78)
• patients in group 1a were less likely to experience complications or die than patients in group 3 (OR 0.66)
• patients in group 2 were less likely to die than patients in group 3 (OR 0.38)
• adjustment for the hospital of admission attenuated the association between initiation of statin therapy & the composite end point (OR 0.84)

More general terms

• clinical trial