NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)

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Introduction

5-armed multicenter NIH-funded study ,

1583 patients > 40 years of age, 64% female

all patients with knee pain > 6 months duration & radiographic evidence of osteoarthritis ,

Glucosamine 500 mg TID

Chondroitin sulfate 400 mg TID

Glucosamine plus Chondroitin sulfate

Celebrex 200 mg QD

Placebo ,

Acetaminophen, up to 4 g/day, for additional pain relief ,

Patients evaluated at baseline, 4,8,16 & 24 weeks

Primary outcome measure: 20% improvement from baseline (WOMAC pain severity scale) ,

Results:

More general terms

Additional terms

References

  1. Prescriber's Letter 12(12): 2005 Glucosamine, Chondrotin and Selenium: Recent Osteoarthritis Research Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=211215&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. Questions and Answers: NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) http://nccam.nih.gov/news/19972000/121100/qa.htm
  3. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16495392
    Hochberg MC. Nutritional supplements for knee osteoarthritis--still no resolution. N Engl J Med. 2006 Feb 23;354(8):858-60. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16495399