Women's Health Initiative: Antihypertensives and Cardiovascular Death
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Introduction
Study characteristics:
- 15,787 hypertensive postmenopausal women without other known cardiovascular disease
- mean follow-up 6 years
Treatment:
- monotherapy
- combination therapy (4493 women)
Outcome: death from cardiovascular disease
Results:
- monotherapy
- Ca+ channel blocker associated with greater risk than diuretic (HR = 1.55)
- beta-blocker & ACE inhibitor not associated with increased risk relative to diuretic
- combination therapy
- combination of Ca+ channel blocker + diuretic associated poorest outcome (HR = 1.85 relative to beta-blocker + diuretic)
- ACE inhibitor + diuretic did not differ from beta-blocker + diuretic
More general terms
References
- ↑ Journal Watch 25(2):15, 2005 Wassertheil-Smoller S, Psaty B, Greenland P, Oberman A, Kotchen T, Mouton C, Black H, Aragaki A, Trevisan M. Association between cardiovascular outcomes and antihypertensive drug treatment in older women. JAMA. 2004 Dec 15;292(23):2849-59. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15598916