chronic nasal colonization with Staphylococcus aureus
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Epidemiology
20-40% of normal individuals
Pathology
- teichoic acid may be an adhesion molecule produced by Staphylococcus that facilitates adhesion to nasal epithelium
Complications
- increased risk of postoperative Staphylococcal infections
Management
- eradication with topical nasal mupirocin (resistant strains have emerged)
- mupirocin, in conjunction with daily chlorhexidine gluconate baths[2]
More general terms
References
- ↑ Journal Watch 24(7):56, 2004 Weidenmaier C et al Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections. Nat Med 10:243, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14758355
- ↑ 2.0 2.1 Huang SS, Septimus EJ, Kleinman K et al Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs. A Randomized Clinical Trial. JAMA. 2023;330(14):1337-1347 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37815567 https://jamanetwork.com/journals/jama/fullarticle/2810510
- ↑ Miller LG, et al. Decolonization in Nursing Homes to Prevent Infection and Hospitalization. N Engl J Med. 2023. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37815935 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37815935