folate-sensitive fragile site FRA10A expression

Epidemiology

• rare

Pathology

• chromosomal breakage under specific cell culture conditions

Genetics

• expansion of a polymorphic CGG repeat within 5'UTR of FRA10AC1 gene

Clinical manifestations

• no distinct phenotype has been associated with expression of FRA10A
• suggested mental retardation, tumorigenesis, neurological disorders

More general terms

• genetic syndrome (multisystem disorder)