nicotine lozenge (Commit)

Introduction

Tradename: Commit.

Indications

• Smoking cessation:

Contraindications

• ok for patients with dental disease

Dosage

• based on 'time to 1st cigarette'
• 4 mg for patients who normally start smoking within 30 minutes of awakening
• 2 mg for patients who normally start smoking > 30 minutes after awakening
• 1 lozenge every 1-2 hours for 6 weeks, then every 2-4 hours for 3 weeks, then 4-8 hours for 3 weeks
• do NOT chew lozenges; this causes nicotine to release too rapidly
• may be used with nicotine patch

* 2-mg or 4-mg QD) efficacy, 35% at 4 weeks, 30% at 12 weeks, 25% at 26 weeks, & 20% at 52 weeks, & similar frequency of adverse effects

Pharmacokinetics

• acidic drinks reduce absorption
  • avoid orange juice, coffee, soft drinks before & during use of Commit

Adverse effects

• dyspepsia
• see nicotine

More general terms

• pharmacologic combination

Components

• nicotine