zilebesiran

Indications

• add-on treatment for inadequately-controlled hypertension

Dosage

• single subcutaneous dose of 600 mg*

* effective for 6 months

Adverse effects

• injection-site reactions
• hypotension
• hyperkalemia
• acute renal failure
• few serious adverse events

• drug adverse effects of antihypertensive agents

Mechanism of action

• RNA interference
  • targets hepatic synthesis of angiotensinogen
  • reduces serum angiotensinogen levels & systolic blood pressure

More general terms

• antihypertensive agent