drug-induced ANCA-associated vasculitis
Jump to navigation
Jump to search
Etiology
- strongest associations with*:
- hydralazine
- minocycline
- antithyroid drugs (propylthiouracil, methimazole, carbimazole)[1]
* similar to drug-induced lupus erythematosus
Laboratory
- pANCA in serum; anti-myeloperoxidase in serum (positve)
- urinalysis consistent with crescentic glomerulonephritis[1]
- otherwise similar to drug-induced lupus erythematosus
Diagnostic procedures
- renal biopsy: necrotizing & crescentic pauci-immune glomerulonephritis[1]
Differential diagnosis
Management
- removal of offending agent
- immunosuppressive therapy
More general terms
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Medical Knowledge Self Assessment Program (MKSAP) 20 American College of Physicians, Philadelphia 2025
- ↑ Santoriello D, Bomback AS, Kudose S, et al. Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine. Kidney Int. 2021;100:440-6. PMID: https://pubmed.ncbi.nlm.nih.gov/33857570