disease interaction(s) of obesity with heart failure
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Pathology
- obesity is associated with excessive adipocyte-derived aldosterone secretion, independent of the renin-angiotensin-aldosterone axis
Management
- mineralocorticoid receptor antagonists may be more effective in patients with heart failure & obesity
- finerenone of benefit in obese patients with heart failure across the spectrum of LVEF[1]
More general terms
References
- ↑ 1.0 1.1 Butt JH, Henderson AD, Jhund PS et al Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: Prespecified Analysis of FINEARTS-HF. J Am Coll Cardiol. 2024 Dec 4:S0735-1097(24)10423-8. PMID: https://pubmed.ncbi.nlm.nih.gov/39665701 Free article.